In order to investigate the effects of Soonkiwhalwheultang and Gamisoonki -whalwheultang on both endotoxin- induced blood stasis model(hereafter Endotoxin Model) and hydrocortisone acetate-induced blood stasis model(hereafter HA Model).
Half of rats were treated with endotoxin(0.4mg/kg, single IV, into caudal vein) for Endotoxin Model. Thereafter, they were orally administrated water extract of Soonkiwhalwheultang or Gamisoonkiwhalwheultang respectively. Finally, the number of platelet, fibrinogen, prothrombin time and hematocrit, were measured after sacrifice.
The remainder rats were treated with hydrocortisone acetate(10mg/kg, daily IM for 7 days into the muscular rump) for HA significantly decreased. Together, they were orally administrated for 7 days water extract of Soonkiwhalwheultang or Gamisoonkiwhalwheultang. Finally, the number of platelet, fibrinogen, prothrombin time and hematocrit, were measured after sacrifice.
The results were summarized as follows
1. The number of platelet was small increased in Soonkiwhalwheultang and Gamisoonkiwhalwheultang groups as compared with the control group in Endotoxin Model and HA Model.
2. Fibrinogen level was significantly increased in all administration groups as compared with control group in Endotoxin Model and HA Model.
3. Prothrombin time was significantly shortened in all administration groups as compared with control group in HA Model.
4. Hematocrit was significantly increased in all administration groups as compared with control group in Endotoxin Model and HA Model.
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